| ncRNA name | hsa-miR-222 |
| ncRNA Category | miRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | RB samples, normal retinal tissues; human RB cell line Y79 |
| Methods | qRT-PCR, transfection, MTT assay, colony formation assay, apoptosis detection assay, Matrigel invasion assay, and wound-healing assay |
| Expression pattern | up-regulated |
| Functional description | Overexpression of miR-221/222 was associated with tumor invasiveness in patients with RB. Targeting of miR-221/222 induced apoptosis and inhibited Y79 cell proliferation, migration, and invasion in vitro. |
| PubMed ID | 29843209 |
| Year | 2018 |
| Title | Upregulated miR-221/222 promotes cell proliferation and invasion and is associated with invasive features in retinoblastoma. |
| Drug-related ncRNA | NO |
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